iloperidone raises levels of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. Iloperidone is often a time-dependent CYP3A inhibitor and could lead to greater plasma amounts of drugs predominantly eliminated by CYP3A4.
Utilization of benzodiazepines, including diazepam, each utilized alone and together with other CNS depressants, may perhaps produce likely fatal respiratory depression
&Increase is common with the outside group, which we expect is smart - when we're from the thick of something, we often wish to practical experience a much better temper now.
buprenorphine transdermal and scopolamine equally maximize sedation. Steer clear of or Use Alternate Drug. Limit use to individuals for whom different cure options are insufficient
diltiazem will raise the amount or outcome of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
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Seizures and seizure-like exercise documented; weigh this probable danger towards Positive aspects prior to prescribing therapy to people using a history details of seizures, like those obtaining anti-epileptic medication or who've risk things that will decreased seizure threshold
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cyclosporine will increase the degree or effect of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
Comment: Coadministration of anticholinergic drugs and glucagon improve the threat of gastrointestinal adverse reactions resulting from additive results on inhibition of gastrointestinal motility. .
aprepitant will raise the stage or outcome of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
voriconazole will improve the degree or impact of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
Sometimes, benzodiazepine users have designed a protracted withdrawal syndrome with withdrawal symptoms lasting weeks to greater than 12 months
environmentally friendly tea decreases consequences of diazepam by pharmacodynamic antagonism. Insignificant/Importance Unfamiliar. Caffeine ingredient of inexperienced tea may well lessen sedative results of benzodiazepines.